Identifying Novel INI-1 Interacting Proteins

Zach Lewis, Kristy Johnson, Donald Ruhl

Abstract


Atypical teratoid rhabdoid caner (AT/RT) is an aggressive embryonal cancer which affects the human brain’s posterior fossa in early stages of life. The root cause of AT/RT originates during mRNA transcription due to a lack of INI-1 in the SWI/SNF complex. The research conducted was part of a base study analyzing the biological function of proteins which associate with the INI-1as to derive probable biological functions of the said protein. The result of two trials yielded an inconclusively diverse array of possible functions, more trials will have to be conducted to establish a solid precedence for future research.

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References


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