Pregnancy associated breast cancer and its prognosis studied through gene expression analysis

Abstract

The impact of pregnancy on the biology of cancer remains a poor area of prognosis for pregnant women. Interactions with diagnosing at age, stage, and grade remain unknown, regardless of the precision medicine and early diagnosis of such disorders. Breast cancer, specifically diagnosed during or 5-10 years post-childbirth, has fewer studies and poorer outcomes than non-pregnant control patients. It has also been found in epidemiological studies that pregnancy has shown a bidirectional, time-dependent effect on the risk of breast cancer. The rise of these cancers and how their genetic makeup differs from non-pregnant related breast cancer is unknown. It is known, compared to age-matched non-pregnancy-related breast cancers, PABC and PPBC has been characterized by an increased tumor incidence and aggressive nature. Determining whether pregnancy is related to a change in gene expression causing breast cancer and whether these changes are persistent and worse than non-BCP cancers are key predictors for disease prognosis. Also examining these changes, studies have searched for tumor patterns, gene expression changes, and genome sequencing data to find signatures for the molecular characteristics of PABC or PPBC.