Gene Mutations susceptibility to Systemic lupus erythematosus (SLE) risk vary in populations

Abstract

Systemic Lupus Erythematosus (SLE) is a relatively common but complex autoimmune disease characterized by the production of a variety of autoantibodies and has a substantial genetic component. SLE is a significant health problem with about 20,000 annual mortality rate in the United Stattes. Clinical manifestations and disease severity also vary significantly among different ethnicities and populations. Recently, researchers at Oklahoma Medical Research Foundation (OMRF) identified a novel predisposing variant from gene ITGAM (Integrin Alpha M) with strong susceptibility to SLE. Using Real Time Polymerase Chain Reaction (RT PCR), a total number of 5,753 DNA samples of patients and 6,800 DNA samples of healthy individuals were genotyped with ITGAM (rs1143679) primer. The results depicted that ITGAM susceptibility to SLE risk is associated in multiple populations (Colombians, European Americans, British, Mexicans, Hispanic Americans, and African Americans) but not in Korean and Japanese populations. The objective of this review is to analyze the association between ITGAM and SLE in eight different populations.