Chemotherapy Resistance in Cancer Cells

Abstract

Chemotherapy is a very common treatment associated with cancer. Unfortunately, many cancers have developed a resistance to these chemotherapeutic agents. Mutations in the expression of deoxycytidine kinase (DCK) lead to gemcitabine (GEM)-resistant pancreatic cancer cells. An arrested S-phase due to epidermal growth factor receptor (EGFR) in breast cancer can cause multidrug resistance (MDR). Resistance can also occur because of the microenvironment. Mesenchymal stem cells (MSCs) are mediators of resistance to chemotherapy. Each of these has a treatment or suggestion to reduce or eliminate the factors that cause the resistance and continue to increase the efficacy of chemotherapy treatment.