A review of the study: UV –B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo

Allison Bates


The objective of the manuscript under review is to ask the following question and answer it. Can UV radiation induce antimicrobial peptides in vitro and in vivo? UV radiation comes from our sun and is known to cause retinal damage if looked directly at and also skin cancer. UV radiation can be synthesized and used in the medical field and laboratories in suppressing the immune system in order to combat an immune disease or other problem. It is still unclear the long term effects of UV radiation on a patient and how it alters their skin microbiome. It is known that UV radiation can disturb the epidermal barrier which naturally coincides with an increased risk of bacterial infections. However, this is not true. Scientists have been speculating why the correlation of UV radiation and epidermal barrier does not lead to an increase in bacterial infections.

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