9189358542

Abstract

Individual cell and tumor profiling is used to help aid breast cancer treatment, through gene-targeted therapy. Both articles, discussed below, show that there is a high level of genetic heterogeneity present in cancerous tumors. These tumors, can be analyzed and profiled to reveal  single cell genomes and characteristics. This reveals the different kinds of cancerous and noncancerous cells that make up the tumor. Different subtypes of the cancers, as well as immune cells and the microenvironment were identified, along with their roles in cancer cell development, proliferation, and prevention. By knowing the level and characterization of the heterogeneity in the cancer tissue, researchers helped identify specific targets for treatment, including T cells and Oct-4A.  This is important because if we are able identify cancers and group them into subtypes, treatment options will broaden and allow for improved prognoses. The results of this study showed 91 % accuracy in relation to subtyping breast cancers. Researchers were able to classify 515 different cells within the tumors and identify 11 different clusters of patterns among them. Overall, the data collected was supported the validity of genomic profiling.