Breast and Ovarian Cancer and BRCA Gene

Christopher J Hocevar


Genetic cancer is important to gain knowledge in how to battle certain gene mutations in Ovarian and Breast cancers. It is interesting to see what kind of mutations and proteins are inherited, seeing that BRCA1 or BRCA2 is inherited in more than 16% of Ovarian Cancer patients. This scientific paper is trying to address inherited mutations and exactly which ones are the cause of cancer, specifically Ovarian and Breast Cancer with Breast Cancer being the most common cancer in Women and Ovarian cancer estimating 5% of cancer related deaths in Women. Current unanswered questions; how to stop the mutations, is it possible to stop the gene mutation from being inherited, as well as do these Ovarian inherited mutations cause Breast cancer without causing Ovarian cancer first. Included are studies that worked on establishing the difference in BRCA1 and BRCA 2 in the country of Belarus, the study of inherited inflammation and its association to Ovarian Cancer, a study of the specific modifiers of BRCA1/2, and research into the tumor suppressor causing Ovarian Cancer. This paper will be a summary of BRCA1 and BRCA2 mutation genes as well as the connection of Breast and Ovarian Cancer. It will also go into detail of the mutations and tumor suppressors found in Ovarian Cancer and what they cause.

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