The regulation and defectiveness of T cell antigen-receptor signal transduction with the help of kinase and phosphatase for regulation and defectiveness when lacking thymic isoform of p59 (fyn)

Abstract

T cell antigen-receptor signal transduction is helped by LAT (linker for activation of T cells), SLP-76 (SH-2 containing leukocyte protein 76), and Itk (inducible T cell kinase). With the help of CD3, CD4 or CD8, reorganization of the cytoskeleton as well as transcription activation can be carried out. This improves the TCR signaling as a whole. With the presence and balance of kinase and phosphate activities, signal transduction can be regulated but with thymic isoform lacking, signal transduction is defective. This micro review will discuss how T cell antigen receptor signal transduction works as well as why with a balance of kinase and phosphate it is regulated but with a lack of thymic isoform it is defective.