Sirtuins and Age-Related Diseases

Abstract

For the time since their discovery, the sirtuin proteins of deacetylase enzymes have been involved in the extension of the life expectancy of certain organism and individuals. The main sirtuins involved in the cytoplasm and mitochondrion involve the SirT1 and SirT3. Both of these sirtuins demonstrate capabilities to extend the life span in biology. They either slow the age related diseases or suppress them depending on the protein involved. These proteins need physiological effects in order to carry out their processes and pathways.  This review will cover all of these ideas, and show how many of these diseases are either slowed or treated before-hand or after the initial disease has taken place.