Antibiotic Development and Optimization Based on Bacterial Protection and Evolution

Benjamin Fransen



Bacterial infections are the main component in the environment that plague humans in the sense of illness and health. There are thousands of bacterial pathogens identified and many more that we know little about. There is constant change in the susceptibility of these bacteria to our antibiotic armament that we posses due to evolution, mutation and the defense mechanisms these pathogens have. There is a diversity of problems because of these natural pathogenic defenses that must be overcome in order to continue on in successfully combating bacterial infection. These problems are identifying bacterial defenses and how they function, finding new alternatives to antibiotics that no longer work as well due to bacterial evolution and developing these new antibiotic’s in ways that are effective cost wise and are applicable in the sense of experimental efficiency. New progress in this field has found important aspects of bacterial defense such as the role of indole as well as new antibiotic potentials like arylomycins and optimizing production of these antibiotics through secondary metabolic pathways. Many similar aspects are currently under research to combat problems of development and production of antibiotic agents.

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