Protein Synthesis Inhibitors Effects on Long-term Memory

Abstract

The model for the molecular basis of memory is that memory formation occurs in two stages. There is an early temporary stage independent of protein synthesis and a long-term memory phase dependent on training-initiated de novo protein synthesis. The stage pertaining to the formation of long-term memory has been thoroughly researched in numerous studies through the injection of drugs, which inhibit protein synthesis in the brain. Through inhibiting protein synthesis, it has shown no effect on short-term memory but has greatly impaired the formation of long-lasting memories. However, some recent studies have attempted to nullify the effects of these protein synthesis inhibitors. These studies have shown a weakening in amnesia generated by protein synthesis inhibitors by using stimulant drugs, local anesthetics, and inhibitory avoidance training to counteract the effects of the inhibitor. However, the resulting attenuation in these instances is not consistent with the contemporary view that protein synthesis initiated by training is necessary for memory formation.