p97’s roles in muscle atrophy, mitochondrial membrane protein turnover, and the effects of p97 inhibition

Abstract

The valosin-containing protein, p97, is ATP-driven ubiquitin-selective chaperone whose primary function is the extraction and degradation of a wide variety of protein complexes.  This microreview will summarize recent studies in the cellular functions of p97 in relation to degradation of muscle proteins, regulation and turnover of outer mitochondrial membrane, and the effects of p97 inhibition.