Regenerative Mice Provide Insights into Biomedical Tissue Regeneration

Chelsea Fortenberry


Tissue regeneration is a property that is commonly associated with non-mammalian organisms but recent discoveries have revealed such characteristics in mice. The unique regenerative properties of MRL and Acomys mice have provided insights into regenerative potentials for the biomedical advancing of myocardial regeneration and skin regeneration respectively. The two studies linked the existence of blastema like structures at the healing site of wounds and the lack of scar formation to the success of the tissue regeneration. Contributing differences between non-regenerators and regenerators aiding in regenerative capabilities include cell cycle variation, collagen I and III ratios, and long-term cell proliferation. However, the mechanism for which the cell actually maintains the regenerative features remains unknown and needs further investigation.

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