Where Wnt is going: Revolutions in Wnt Research

Abstract

     Wnt proteins are important metazoan signaling molecules that help regulate stem cell maintenance, cell proliferation, and cell differentiation. Mutations in Wnt genes are associated with several hereditary diseases, including bone diseases and cancers. This microreview probes a few current studies that (a) revise and enhance our understanding of the Wnt signaling pathway, and (b) identifies novel targets for cancer treatment. Despite the progress, several features of Wnt signaling remain unknown. Accordingly, a few open questions related to Wnt protein/pathway functions conclude this microreview.