Structure reconstruction of human γ-secretase

Abstract

γ-secretase is a multi-subunit protease complex that cleaves transmembrane proteins in residues within the transmembrane domain. Aberrant function of γ-secretase is thought to result in Alzheimer’s disease. Mechanical understanding of γ-secretase’s function is still limited due to the lack of structural information. The purpose of this review is to summarize some of the finding of an atomic structure of human γ-secretase from a series of papers done by Shi’s lab (Tsinghua University) published in the journal Nature.