Selectively Developmental Synapse Elimination

Abstract

Unwanted synapse elimination, a pivotal part of the early nervous system development, happening in the early postnatal life, critical for the precise formation and refinement of the neuronal circuits and proper brain function, has been studied for decades that how this process takes place. Unfortunately, the underlying mechanism still remains unclear, therefore, more research in this field is required to uncover this mystery mechanism. The purpose of this short review is to summarize the recent progress in this field research and discuss the future research direction.