Mechanism for substrate preference of TET with structural analyses

Abstract

The microreview tells about the recent research about mechanism for the reactions catalyzed by human TET proteins. TET1 and TET2 act more active on 5mC-DNA substrates than on 5hmC/5fC-DNA substrates. The recent research found that substrate recognition does not account for the preference. They proposed a mechanism for the reaction that consists of four steps and the hydrogen abstraction is the rate-controlling step.