Alzheimer’s disease: Insulin- Degrading Enzyme

Abstract

A closer focus is being done as to why progression of Alzheimer’s disease occurs after years of research. There has been no luck on the aspect. One factor that is major to the cause of Alzheimer’s disease is impaired clearance of amyloid beta peptides. Yet it was recently complemented by a potential role of other toxic amyloidogenic species (Kurochkin). Insulin-degrading enzyme is the proteolytic culprit of carious B-forming peptides, both extracellular and intracellular (Kurochkin).