Transcription of Genes Associated with Vitamin B6 Metabolism in Elizabethkingia anophelis R26

Abstract

Elizabethkingia anophelis R26is a commonly found pathogen in enviroments worldwide. Due to a sudden outbreak in the United States, scientists have observed that E.anophelisis highly resistant to several antibiotics, making the ability to cure and prevent the diseases caused by E. anophelis , challenging.. We have investigated further into E. anophelis, specifically into the proteins involved with making Vitamin B6.According to the RAST database five genes are involved with sythesizing this molecule. We now present data showing that these genes demonstrated alterations in transcription when grown in the prescence of beta-lactam antiobiotics , cefotax and iminpenem. This data suggests that vitamin B6 is essential forE.anophelis to survive when exposed to antibiotic stress.