Tumor-secreted miR-214 delivered on T cells to promote tumor growth

Abstract

There is a mysterious link between increased population of CD4+CD25high Foxp3+ regulatory T cells (Tregs) in the tumor and cancer immune. This article gives a mechanism for the first time, in which tumor-secreted miR-214 is delivered to T cells by microvesicles (MVs), then downregulate phosphatase and tensin homolog (PTEN) and promote tumor growth.  The MV delivery of anti-miR-214 antisense oligonucleotides (ASOs) efficiently blocks Treg expansion and suppress tumor growth.