Enzyme-Instructed Self-Assembly of Small d-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells

Abstract

It  is  reported  that  the  molecular  and  cellular  validation  of  enzyme-instructed  self-assembly (EISA)  as  a  multiple  step process  for  selectively  killing  cancer  cells  that  overexpress  alkaline phosphatases  (ALPs) . The  team design the d-tetrapeptides that  can express  their  activity  in  seletively inhibiting  by  the  number ,structure  and  the location of  the  phosphotyrosine  residues .The paper report that unphosophorylated d-tetrapeptides can not kill any cells including normal and cancer cells . monophosophorylated  and  diphosophorylated  d-tetrapeptides have  the  function  of  selectively  inhibiting the  cancer cells , and they will not do harm to normal cells . This can be a progress in anticancer therapeutics.